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1) M. Goldenberg et al., Am. J. Med., S, 792 (1948); H. Giertz and W. Schild, Kiln. Wochschr., 30, 421 (1952): H. Greuel, ibid ., 902. per animal on alternate days throughout the experimental periods. As control groups II and IV were injected with an equal volume of physiological saline or an equivalent iodine ion to MMSI, respectively. Group I was free from injection and cholesterol feeding. MMSI was synthesized from DL-methionine and methyl iodide2). The determination of serum cholesterol was carried out as described by Bennie et al. 3), and that of cholesterol in the liver performed after the procedure of Gungbaum et al. 4). Total lipid in the liver was estimated as an ether-soluble matter and the unsaponifiable matter was deter mined as the residual fraction of the lipid, by treatment with 30% potassium hydroxide. The results are shown in the Table below. The levels of total cholesterol in the sera of the animals, injected with MMSI (Groups III & V) are apparently lowerd as compared with that of the control groups, i.e., animals injected with saline (group II) and sodium iodide (Group IV). These data lead to some support of the view that MMSI might act as a preventing agent against dietary hypercholesteremia . and 2) K. Nakamura and H. Ariyama, Tohoku J. Agr . Res., 9, 269 (1958/59). 3) Z. Bennie et al., Am. J. Med. Technol., 23, 283 (1957).4 ) B. W. Gungbaum et al., Proc. Soc. Exptl. Biol . Med., 94, 613 (1957).

The Preventive Efiect of a S-Methyl Methionine Sulfonium Compound on Dietary Hypercholesteremia