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Citrus peel extract (CPE) has several bioactivities that encompass anti-oxidation, anti-inflammation and anti-melanogenic effect. However, its usage in functional food has been difficult due to uncommon evidence in human trial. The reason of this study is to evaluate the safety and skin brightening effects of natural CPE in human subjects. To enhance its effectiveness in clinical trial, we also used both vitamin C for anti-oxidation and L-cystine for decreasing melanin biosynthesis. All subjects administered 1 test capsule (AP-BF02 including 100mg of CPE, 125mg of vitamin C, 60mg of L-cystine) or placebo for two months. We objectively measured changes in melanin index (MI), skin lightness (L*), and skin color (ITAO). The two investigators also used subjective ratings to analyze skin pigmentation. The MI values were significantly lower in test group, compared with that in placebo group from 4 weeks after. In addition, AP-BF02-intake group had significant improvement in lightness and color at the end of examine period. Consequently, oral supplementation with AP-BF02 can brighten human skin in healthy women without adverse effect.

Effect of Oral Intake of A Mixture Containing Natural Citrus Peel Extract, Vitamin C, and L-Cystine on Skin Brightness in Healthy Women