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Nigella sativa ( N. sativa ) is traditionally used as an immune enhancer in different communities. The aim of this study was to evaluate the effect of  N. sativa  on immunity related parameters in young healthy subjects. This study was a double blind, randomized, placebo controlled clinical trial. Fifty-two healthy subjects (48 male and 4 female) 18-25 years old were enrolled in the study. They were randomly divided into four groups; the first received charcoal capsules and served as controls and the other three received 0.5, 1 g, and 2 g of powdered  N. sativa  capsules, respectively. Two blood samples were obtained from all participant, before initiation of the trial and at the end of the four weeks intervention. One sample was used for routine health screening by evaluating liver and renal functions as well as complete blood count and differential. The second sample was used to measure certain cytokines including; IL-1, IL-4, IL-6, IL-10, and TNF. A third and fourth samples were obtained from the last cohort of subjects before and after treatment; the third was used for measuring immunoglobulins and CD profile and the fourth for evaluating certain gene expressions (INF-γ, NF-κ-B, TNF-α, IL-1β, IL-13, IL-8, and IL-6). Only 1 g dose of  N. sativa  produced a significant elevation in total lymphocyte count, CD3+ and CD4+ counts. One gram  N. sativa  increased the absolute lymphocyte count from 1850±0.24 to 2170±0.26 (p=0.008), CD3+ from 1184.4±75.60 to 1424±114.51 (p=0.009), and CD4+ from 665.6±141.66 to 841±143.36 (p=0.002).  This elevation in T cells was lost by increasing the dose of  N. sativa  to 2g. The rest of the parameters were not changed significantly in all doses.   The results show a promising immunopotentiation effect of  N. sativa  by elevating helper T cells and the optimum dose for young age group seems to be 1 g.

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Effect of Nigella sativa on general health and immune system in young healthy volunteers; a randomized, placebo-controlled, double-blinded clinical trial