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Accelerated vascular smooth muscle cell (VSMC) proliferation is implied in cardiovascular disease and significantly contributes to vessel lumen reduction following surgical interventions such as percutaneous transluminal coronary angioplasty or bypass surgery. Therefore, identification and characterization of compounds and mechanisms able to counteract VSMC proliferation is of potential therapeutic relevance. This work reveals the anti-proliferative effect of the natural product capsaicin from  Capsicum  spp. by quantification of metabolic activity and DNA synthesis in activated VSMC. The observed  in vitro  activity profile of capsaicin warrants further research on its mechanism of action and potential for therapeutic application.

Capsaicin from chili (Capsicum spp.) inhibits vascular smooth muscle cell proliferation