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The genetic background of ischemic vascular disease is actively being explored. Several studies have shown that inhibition of  APOC3  significantly reduces plasma levels of apolipoprotein C3 and triglycerides. Recently, the TG and HDL Working Group and Jørgensen  et al.  reported that loss-of-function mutations in  APOC3  are associated with decreased triglyceride levels and a reduced risk of ischemic vascular disease in European and African individuals. We performed a replication study in 4470 Chinese participants. The coding regions of  APOC3  were amplified and re-sequenced. However, only synonymous and intronic variants with no functional consequences were identified. None of the loss-of-function mutations reported in European and African individuals were observed. Therefore,  APOC3  may not be an ideal predictor for risk of ischemic vascular disease in the Chinese population.

APOC3 may not be a predictor of risk of ischemic vascular disease in the Chinese population