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Background:  Hyperuricemia is a pathological condition associated with risk factors of cardiovascular disease. In this study, three genetic polymorphisms were genotyped as predisposing factors of hyperuricemia.   Methods:  A total of 860 Mexicans (129 cases and 731 controls) between 18 and 25 years of age were genotyped for the  ABCG2  (Q191K),   SLC22A12  (517G>A), and   XDH  (518T>C) polymorphisms, as predisposing factors of hyperuricemia. Biochemical parameters were measured by spectrophotometry, while genetic polymorphisms were analyzed by real-time PCR. An analysis of the risk of hyperuricemia in relation to the variables studied was carried out using a logistic regression.   Results:  Male sex, being overweight or obese, having hypercholesterolemia or having hypertriglyceridemia were factors associated with hyperuricemia (  p  ≤ 0.05). The  ABCG2  polymorphism was associated with hyperuricemia (OR = 2.43, 95% CI: 1.41-4.17,  p  = 0.001) and hypercholesterolemia (OR = 4.89, 95% CI: 1.54-15.48,  p  = 0.003), employing a dominant model, but only in male participants.   Conclusions : The  ABCG2  (Q191K) polymorphism increases the risk of hyperuricemia and hypercholesterolemia in young Mexican males.

Polymorphisms of the genes ABCG2, SLC22A12 and XDH and their relation with hyperuricemia and hypercholesterolemia in Mexican young adults