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Porphyromonas gingivalis  has virulence factors such as gingipain and lipopolysaccharide, causing bacteremia to reach the brain and activate neuroinflammatory release cytokines. This study analyzed the effect of the co-culture of neuron cells with  P. gingivalis    coated with anti -P. gingivalis    antibodies against cytokines produced by neuron cells. The gene expressions of the  TNF ,  IL1B ,  iNOS2  in neurons was evaluated using RT-qPCR. The results showed that  P. gingivalis    coated with anti -P. gingivalis    antibody before co-culture with neuron cells could decrease the gene expression of  TNF ,  IL1B ,   and  iNOS2  of neuron cells.

f1000research

Expression of TNF, IL1B, and iNOS2 in the neural cell after induced by Porphyromonas gingivalis with and without coating antibody anti-Porphyromonas gingivalis