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The network science-based determination of driver nodes and sensor placement has become increasingly popular in the field of dynamical systems over the last decade. In this paper, the applicability of the methodology in the field of life sciences is introduced through the analysis of the neural network of Caenorhabditis elegans. Simultaneously, an Octave and MATLAB-compatible NOCAD toolbox is proposed that provides a set of methods to automatically generate the relevant structural controllability and observability associated measures for linear or linearised systems and compare the different sensor placement methods.

Network-based Observability and Controllability Analysis of Dynamical Systems: the NOCAD toolbox