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Background:Staphylococcus aureus  is a significant pathogen implicated in numerous nosocomial and community-acquired infections. The Panton–Valentine leukocidin (PVL) can be associated with severe necrotizing diseases such as pneumonia, skin and soft tissue infection (SSTI).     Methods : In total, 96  S. aureus  isolates were obtained from patients presenting with wounds (n=48) and soft tissue infections (SSTIs, n=48). These were characterized based on their antimicrobial susceptibility profile, the possession of virulence genes (e.g. capsular type, PVL), accessory gene regulator (  agr ) type, and the staphylococcal protein A (  spa ) type. The production of the PVL protein was assessed by western blotting.    Results : All isolates were susceptible to methicillin. The resistance was highest to penicillin (97.9%), followed by trimethoprim/sulfamethoxazole (85.4%) and tetracycline (10.4%). The PVL gene was found in 83.3% of isolates from SSTIs and in 79.2% of isolates from wound. Of these, 53 (68%) produced PVL as assessed by western blotting. The most prevalent  spa  type was the t084 (78.1%, n=75) and, majority of the isolates carried   agr 2 (82.3%, n=79).    Conclusions : Prevalence of antibiotic resistant PVL-positive methicillin susceptible  S. aureus  strains has severe implications on PVL mediated infections.

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Characterization of Panton–Valentine leukocidin-positive Staphylococcus aureus from skin and soft tissue infections and wounds in Nigeria: a cross-sectional study