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Background:  α-arrestins are a family of proteins that are implicated in multiple biological processes, including metabolism and receptor desensitization.  Methods:  Here, we sought to examine the roles of α-arrestins in the longevity of  Caenorhabditis elegans  through an RNA interference screen.  Results:  We found that knocking down each of 24 out of total 29  C. elegans  α-arrestins had small or no effects on lifespan. Thus, individual  C. elegans  α-arrestins may have minor effects on longevity.  Conclusions:  This study will provide useful information for future research on the functional role of α-arrestins in aging and longevity.

RNAi targeting Caenorhabditis elegans α-arrestins has small or no effects on lifespan