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The present study was carried out to determine the effects of sub-chronic thinner addiction on the oxidant-antioxidant balance and oxidative stress on certain tissues and the possible protective effect of safranal against thinner toxication in rats. Wistar albino rats were divided into 4 groups as follows: control (C), safranal (S), thinner (T) and thinner + safranal (T+S). Each group was composed of 10 rats, and the study lasted 8 weeks. After completing the animal studies malondialdehyde (MDA), reduced glutathione (GSH), nitric oxide (NO x ) metabolites, total antioxidant capacity (TAS) and total oxidant capacity (TOS) levels were determined from liver, lung, brain, kidney and testis tissues of the rats. Oxidative stress was determined in the lung, liver, kidney, testis and brain tissues of the rat groups that inhaled thinner. In T + S group, it was observed that safranal either eliminated or mitigated oxidative stress that developed in tissues through decreasing MDA and TOS levels and increasing GSH and TAS levels and caused significant decreases in NO X  levels in all tissues. As a result, it was determined that safranal, although not uniform for all tissue types, had a protective potential against the damaging effects of oxidative stress caused by sub-chronic thinner inhalation.

Effects of Safranal on Tissue Oxidative Stress in Sub-Chronic Thinner-Addicted Rats