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Steroid 3β-ol dehydrogenase activity in some transplantable tumors of mice was reported in the previous paper. In this study, activities of this enzyme and of certain related enzymes were examined histochemically in their host organs.Steroid 3β-ol dehydrogenase activity was highly positive in the renal distal convoluted tubular epithelium of mice with Gardner 107 testicular interstitial cell tumor or ovarian granulosa cell tumor, both of which always showed a positive activity of the enzyme. However, the activity was undemonstrable in the kidneys of non-tumor or osteosarcoma-bearing mice.ALPase activity did not increase in the kidneys of osteosarcoma-bearing mice, despite a marked elevation of serum ALPase of the host.The degree of the activity of steroid 3β-ol DH, of G-6-PDH, of LDH or of ALPase varied in the lungs and livers, but no any difference was found between the activities in the similar organs of mice with or without tumors.

HISTOCHEMICAL STUDIES ON STEROID 3β-ol DEHYDROGENASE AND RELATED ENZYMES IN HOST ORGANS OF TUMOR-BEARING MICE