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The purpose of this study was to show the immunohistochemical activity of the commercialized antibodies of oncogene products and related enzymes using extremely small lesions of tubular adenocarcinomas in human stomachs. Seven lesions among 11 carcinoma lesions (63.6%) measuring 1 mm in diameter and 8 among 8 carcinoma lesions (100%) measuring 1 approximately 5 mm in diameter showed positive reaction in their cytoplasms for c-myc oncogene products (6E10). In immunohistochemical staining for c-erbB-2 gene product no carcinoma lesions (0%) measuring 1 mm in diameter were positive in their cytoplasms and all carcinoma lesions (100%) measuring 1 approximately 5 mm in diameter were positive in their cytoplasms. One lesion (1/11 lesions, 9.1%) measuring 1 mm in diameter and 6/8 lesions (75%) showed positive reactions in their cytoplasms for protein kinase C (Type III) immunohistochemically (x2 analysis, p < 0.05). All gastric minute tubular adenocarcinoma lesions in this study were positive in their cytoplasms for lysozyme immunohistochemically.

acta histochemica et cytochemica

Immunohistochemical expression of c-myc oncogene products, c-erbB-2 gene product, protein kinase c and lysozyme in gastric super minute tubular adenocarcinomas(measuring up to 1mm in diameter).