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promonocytes or monoblasts in the circulating blood has not hitherto been reported by any worker who used [3H]TdR. This indicates that [14C]A is more effective for labeling monocytic cells than is [3H] TdR. By treatments with RNase or DNase or both, it was confirmed that the observed labeling of monocytic cells with [14C]A was chiefly due to the incorporation of labeled adenine into DNA. From the biochemical view point, it was suggested that monocytic cells have a limited capacity for de novo adenine synthesis and because of this

The use of (14C)adenine for autoradiographic labeling of blood monocytes and their precursor cells in the bone marrow of rats.