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Neoplastic endocrine cells in the carcinomas of the stomach and small intestine of Wistar male rats, induced by MNNG or ENNG, were examined by histochemical, immunohistological and ultrastructural methods. Detection rates of argyrophil and argentaffin cells in the gastric cancers were 60% and 34.3%, respectively. MNNG induced small intestinal carcinomas contained argyrophil cells in 78.3% and argentaffin cells in 65.2%. Of 205 carcinomas of the small intestine induced by ENNG, 115 lesions (56.1%) contained argyrophil cells and 69 lesions (33.7%) contained argentaffin cells. In some of the cases, gastrin, glucagon and somatostatin were demonstrated in the tumor cells by the immunoperoxidase technique. Ultrastructurally, intracytoplasmic granules were observed, and a special form of endocrine cell which contained two different types of intracytoplasmic granules was also found (endocrine-exocrine cell). This latter finding indicates a multidifferentiating potentiality of tumor cell. Moreover, it would appear that these endocrine cells can arise from undifferentiated stem cells, and that the endocrine cells of the gastrointestinal tract are of the endodermal origin.

acta histochemica et cytochemica

Histochemical, immunohistological and ultrastructural studies on neoplastic endocrine cells in carcinomas of the glandular stomach and small intestine of rats.