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The developmental change of LDH isozyme pattern was studied by disc electrophoresis in brains from embryonic or fetal rats to adult ones. Although a predominance of M-subunit was evident during the prenatal period, a gradual increase of H-subunit was confirmed in rat fetal brains. This tendency grew stronger after birth. Moreover, in regard to regional difference in the LDH isozymic pattern of rat brains, the cerebellum showed the highest H/M ratio, followed by the gray matter of parietal lobe and diencephalon.

DEVELOPMENTAL CHANGE AND REGIONAL DIFFERENCE OF THE LACTATE DEHYDROGENASE ISOZYME PATTERN IN RAT BRAIN