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Background and Objective: Prevalence of Diabetes mellitus as a group of metabolic diseases is increasing. Abnormal lipid profile in diabetic patients is major risk factor for cardiovascular disease. According to studies, polyunsaturated fatty acid (PUFA) effect on lipid profile. We evaluated the association between walnut consumption as a source of PUFA and high-density lipoprotein cholesterol (HDL-C) in prediabetic patients. Methodology: Four hundred eleven (411) first-degree relatives of T2DM male and female 35 to 55 year of age were included in the present study. Dietary intake was assessed with three days record and record’s contents were changed to grams. Biochemical assessments were done according to the standard protocol. Results: Findings show positive associations between walnut consumption and HDL –C level (p=0.01). No other significant associations were observed between other blood lipid components, glycemic control parameters and walnut consumption. Conclusions: Walnut consumption may improve HDL-C in prediabetes patients who were the first-degree relatives of type two diabetic patients.

The effect of walnut consumption on lipid profiles of the first-degree relatives of type two diabetes mellitus patients (T2DM) with prediabetes