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A high dose (200mg/kg) of isopropyl methanesulfonate (iPMS) induced a high frequency of postimplantation loss in postmeiotic male germ cell stages, but the frequency of eggs with chromosome aberrations observed at the first cleavage metaphases was very low. Therefore, we suggest that the postimplantation loss in dominant lethal mutations induced by iPMS is mainly attributable to the alteration of subchromosome material at the first cleavage metaphases.

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Relationship between chromosome aberrations at the first cleavage metaphases and postimplantation loss in dominant lethal mutations induced by isopropyl methanesulfonate.