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In this study, we aimed to establish the rabbit VX2 limb tumor model, and then prepare a "necrotic zone" as a safe margin by volumetric modulated arc therapy and simultaneous integrated boost (VMAT-SIB) technique applied in the areas where the tumor is located adjacent to the bone (GTVboost area).

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Application of Volumetric Modulated Arc Therapy and Simultaneous Integrated Boost Techniques to Prepare “Safe Margin” in the Rabbit VX2 Limb Tumor Model