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Abnormal regulation of Wnt/beta-catenin signaling and subsequently increased beta-catenin expression have been found to be involved in the proliferation and growth of colon cancer cells. Whether the down-regulation of beta-catenin in colon cancer may result in compromised invasion and migration in vitro still remains to be determined.

Small interfering RNA-mediated downregulation of beta-catenin inhibits invasion and migration of colon cancer cells in vitro