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The intention of this study was to examine the determinants of plasma fibrinogen concentrations in healthy Japanese male workers. A cross-sectional study was conducted in 1998 among 1,044 (male 975, female 69) employees aged 30-59 years in Osaka, Japan. The overall mean value of plasma fibrinogen concentration was 236.4 +/- 47.6 mg/dl. There was a dose-response relationship between cigarette smoking and plasma fibrinogen concentration. Plasma fibrinogen concentration was associated with age, body weight, body mass index, white blood cell count and CPITN score, and inversely associated with serum HDL cholesterol in male nonsmokers. Plasma fibrinogen was not related to physical exercise, alcohol consumption or dietary factors. This study confirms the relationship of known coronary risk factors to plasma fibrinogen concentration in Japanese male factory workers, and suggests that smoking and periodontal disease are related to plasma fibrinogen concentrations.

nippon eiseigaku zasshi/nihon eiseigaku zasshi

A Cross-Sectional Study on the Relationship of Plasma Fibrinogen Concentration and Age, Physical Fitness, Lifestyle and Health Examinations of Healthy Japanese Males.