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Diurnal variations were recorded of 10 substances from the urine of 22 healthy women, ranging from 32 to 65 years of age. Twenty-four-hour urine collections were done at each micturition and blood samples were taken on the same day. From the data, it was examined whether the use of creatinine ratio as a measure of the completeness of a 24-hour urine samples was reliable. The results were as follows: 1. Maximum/minimum concentration ratios of various urinary substances were 1.2-4.6, 1.9-9.0, 1.311, 1.3-8.0, 1.6-12, 1.5-12, 1.7-11, 1.8-9.8, and 2.0-12, for (specific gravity-1) ×1,000, creatinine, urea nitrogen, uric acid, calcium, inorganic phosphorus, cadmium, zinc, and copper, respectively. There were

Studies of Diurnal Variations and Incorporation into Creatinine Ratios in the Contents of Urine