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Toxic effects of such organic mercury compounds as methylmercury and such heavy metals as mercury have long been recognized. Interest in these substances has recently increased as a result of anxiety over hazards that may be caused by pollution. Many different types of studies have been done and much information is now available an these toxic substances. However, the modes of action of some substances are very complex and are still unknown. In discussing modes of action, the importance of a biochemical lesion has been suggested. In this paper, I report the effects of the organic mercury compounds: methyl-, ethyl-, propyl-, butyl-, and phenyl-mercury, and of the heavy metals: mercury, lead, cadmium, copper, zinc, cobalt, and nickel, on the oxidative and phosphorylative systems in mitochondria in an attempt to define their biochemical actions. Most reports have measured the amount of inorganic phosphate in order to estimate the reaction products of oxidative phosphorylation or ATPase activity in mitochondria. To determine the reaction products found in this study, ATP, ADP, and AMP were simultaneously measured using the method described in a previous paper1). This made it possible to obtain remarkable information which connects the reaction products with the patterns of the effects of each substance examined on the enzymatic systems in mitochondria.

nippon eiseigaku zasshi/nihon eiseigaku zasshi

Studies of oxidative and phosphorylative systems in mitochondria. II. In vitro studies of the effects of various organic mercury compounds and heavy metals on rat-liver mitochondria.