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In order to analyze mechanisms through which genes integrated into whole mice influence the expression of mouse genes, we introduced the E1A gene of human adenovirus type 12 into the pronuclei of fertilized mouse eggs. Three (12%) of 26 andthree (6%) of 48 mice that developed from eggs injected with Charon10-gE1A-2 DNA and pSV2-gpt-gEl A DNA, respectively, were found to carry the injected sequences. Multiple copies of the injected DNAs were found integrated into the genomesof these mice. They were arranged mainly in tandem, a head-to-tail form. These mice carrying Charon10-gE1A-2 transmitted the integrated sequences to their progeny. However, the patterns of the transmission were different from mouse to mouse. On the other hand, the mice carrying pSV2-gpt-gE1 A have not so far been confirmed to the capability of transmitting the sequence to their progeny. Comparative analysis of proteins extracted from 6 tissues by two-dimensional gel electrophoresis showed that several proteins were different in their quantities when a mouse carrying Charon10-gE1A-2 was compared to its normal littermate. The MW/pI of these spots were, 27kd/6.4 of lung, and 26kd/5.1, 28kd/5.1, 49kd/5.1, 66kd/5.9, 47kd/6.6, and 24kd/7.1 of pancreatic proteins

Introduction of human adenovirus E1A gene into fertilized mouse eggs.