Open AccessNovel application of sRNA: Stimulation of ribosomal frameshifting: FIGURE 1.
Author(s) -
René C. L. Olsthoorn,
M. LAURS,
F. SOHET,
Cornelis W. Hilbers,
Hans A. Heus,
Cornelis W.A. Pleij
Publication year - 2004
Publication title -
rna
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.037
H-Index - 171
eISSN - 1469-9001
pISSN - 1355-8382
DOI - 10.1261/rna.7139704
Subject(s) - translational frameshift , biology , frameshift mutation , transfer rna , ribosome , gene , translation (biology) , genetics , gene expression , ribosomal rna , regulation of gene expression , transcription (linguistics) , pseudoknot , rna , microbiology and biotechnology , computational biology , messenger rna , mutation , philosophy , linguistics
Small RNAs play an important role in regulation of gene expression in eukaryotic and eubacterial cells by modulating gene expression both at the level of transcription and translation. Here, we show that short complementary RNAs can also affect gene expression by stimulating ribosomal frameshifting in vitro. This finding has important implications for understanding the process of ribosomal frameshifting and for the potential application of small RNAs in the treatment of diseases that are due to frameshift mutations.
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