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Sense-antisense mRNA pairs generated by convergent transcription is a way of gene regulation.  c-fms  gene is closely juxtaposed to the  HMGXB3  gene in the opposite orientation, in chromosome 5. The intergenic region (IR) between  c-fms  and  HMGXB3  genes is 162 bp. We found that a small portion (∼4.18%) of  HMGXB3  mRNA is transcribed further downstream, including the end of the  c-fms  gene generating antisense mRNA against  c-fms  mRNA. Similarly, a small portion (∼1.1%) of  c-fms  mRNA is transcribed further downstream, including the end of the  HMGXB3  gene generating antisense mRNA against the  HMGXB3  mRNA. Insertion of the strong poly(A) signal sequence in the IR results in decreased  c-fms  and  HMGXB3  antisense mRNAs, resulting in up-regulation of both  c-fms  and  HMGXB3  mRNA expression. miR-324-5p targets  HMGXB3  mRNA 3′ UTR, and as a result, regulates  c-fms  mRNA expression. HuR stabilizes  c-fms  mRNA, and as a result, down-regulates  HMGXB3  mRNA expression. UALCAN analysis indicates that the expression pattern between  c-fms  and HMGXB3 proteins are opposite in vivo in breast cancer tissues. Together, our results indicate that the mRNA encoded by the  HMGXB3  gene can influence the expression of adjacent  c-fms  mRNA, or vice versa.

Regulation of closely juxtaposed proto-oncogene c-fms and HMGXB3 gene expression by mRNA 3′ end polymorphism in breast cancer cells