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The dietary need for supplementary vitamin K 3  (sodium menaphthone bisulphite) was determined in weanling male rats of two hysterectomy-derived strains fed on Spillers Laboratory Small Animal Diet (autoclaved). The basal diet had 0.6 ppm of added vitamin K 3  to which further supplements of either 0, 4, 16 or 64 ppm vitamin K 3  were added. There was a significant difference between strains in body-weight gain (P&lt;0.001) but not in plasma prothrombin time. After 14 weeks the mean plasma prothrombin time of rats receiving the basal diet was higher (P&lt;0.01) than the mean of those receiving the supplemented diets; but the three supplemented diets did not differ significantly.

Effect of supplementing a commercial diet with vitamin K3 for males of two strains of rats

Effect of supplementing a commercial diet with vitamin K₃ for males of two strains of rats