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The periarterial nerve electrical stimulation (PNS) at a frequency of 1 or 4 Hz (30-s trains of pulses) readily caused a double peaked vasoconstriction in the canine splenic artery. The treatment with 1 microM L-765,314, a selective and potent alpha1B-adrenoceptor antagonist, markedly inhibited the second peaked constriction, whereas it did not modify the vasoconstrictor responses to exogenous noradrenaline (0.03-1 nmol) and A61603 (1-30 pmol), a selective alpha1A-agonist. A large dose of 10 microM L-765,314 significantly blocked exogenous noradrenaline- and A61603-induced responses. It is concluded that PNS-induced responses are mediated via the postjunctional alpha1B-adrenoceptor subtype.

japanese journal of pharmacology/japanese journal of pharmacology

Effects of L-765,314, a Selective and Potent α1B-Adrenoceptor Antagonist, on Periarterial Nerve Electrical Stimulation-Induced Double-Peaked Constrictor Responses in Isolated Dog Splenic Arteries