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In dogs, rectal temperature was decreased to about 36 degrees C at 2 to 2.5 h after sedation with buprenorphine (0.3 mg/body, i.m.), and hindlimb subcutaneous tissue temperature (T(SC)) in the thigh decreased in a similar manner. T(SC) in the dorsum of the foot showed a greater decrease than that in the thigh. OPC-28326 (4-(N-methyl-2-phenylethylamino)-1-(3,5-dimethyl-4-propionyl-aminobenzoyl) piperidine hydrochloride monohydrate) at doses of 0.3, 1.0 and 3.0 mg/kg, p.o. inhibited the buprenorphine-induced decrease in T(SC) in the dorsum dose-dependently, but had little effect on that in the thigh or rectal temperature. In conclusion, T(SC) in the extremities were more sensitive to core temperature and peripheral circulation.

japanese journal of pharmacology/japanese journal of pharmacology

Effect of Oral OPC-28326, a Selective Femoral Arterial Vasodilator, on Hindlimb Subcutaneous Tissue Temperature in Conscious Dogs Under Buprenorphine Sedation