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In isolated canine epicardial coronary arteries perfused with Krebs-Henseleit solution at 37 degrees C, DN-9693, a newly synthesized selective cyclic AMP phosphodiesterase inhibitor, induced vasodilation in a dose-related manner. The threshold dose for inducing vasodilation to DN-9693 was very small, but the maximum vasodilation was not great. The order of potency for ED20 (20% dilatation) was DN-9693 greater than IBMX greater than aminophylline, but that for ED70 was IBMX greater than aminophylline greater than DN-9693, suggesting that these three PDE inhibitors have different properties.

Effects of DN-9693, a Selective Inhibitor of Cyclic AMP Phosphodiesterase, in Isolated and Perfused Canine Large Coronary Arteries