English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

To clarify if dopamine (DA) synthesis is regulated by D-1 DA receptors located on dopaminergic nerve terminals in the striatum, we investigated effects of D-1 DA receptor agonist and antagonist on striatal 3,4-dihydroxyphenylalanine (DOPA) accumulation induced by gamma-butyrolactone in mice treated with an amino acid decarboxylase inhibitor. SKF 38393, a D-1 agonist, did not affect DOPA accumulation, whereas apomorphine that stimulates both D-1 and D-2 receptors inhibited the accumulation. SCH 23390, a D-1 antagonist, did not antagonize apomorphine-induced inhibition of DOPA accumulation, while YM-09151-2, a D-2 antagonist, reversed it. These results suggest that D-1 type of DA autoreceptors is not involved in the inhibition of in vivo DA synthesis.

D-1 type of dopamine autoreceptors are not involved in the regulation of dopamine synthesis in the striatum.