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It has been reported that the activity of Na, K-activated adenosinetriphosphatase (Na,K-ATPase) in the kidney is reduced by adrenalectomy and that the activity is restored by administration of aldosterone (1, 2). However, with the adrenalectomized rats, the restoration of the enzyme by aldosterone has been shown to take much longer time (i.e. 6-24 hr) as compared with the time (1-2 hr) for the maximal effect of aldosterone on the sodium reabsorption (3). We attempted to determine whether or not aldosterone stimulates Na,K-ATPase in correlation with the enhancement of Na reabsorption in non-adrenalec tomized rats. Male Wistar rats weighing 170-250 g were used. Each animal was given water (3 ml

EFFECT OF ALDOSTERONE ON RENAL Na,K-ACTIVATED ADENOSINE-TRIPHOSPHATASE ACTIVITY IN NON-ADRENALECTOMIZED RATS