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In previous studies (1, 2, 3), we assessed the 9-adrenergic blocking activity of 11 com pounds against the positive chronotropic and inotropic effect of norepinephrine in the isolated and blood-perfused canine sino-atrial (SA) node and papillary muscle preparations with donor animals. The blocking potencies of these compounds on the ,3-adrenergic effects on the cardiac functions were roughly divided in those of propranolol and of pindolol, and also in two groups on the difference of presence or absence of sympathomimetic effect. In this paper, two newly synthesized compounds were compared with the potencies of pindolol and propranolol. The isolated SA node and papillary muscle preparations were perfused at 100 mm Hg with the arterial blood conducted from the carotid artery of a heparinized donor dog by the aid of a peristaltic pump. The experimental setup of these preparations have been described in detail in previous papers (4, 5). Drugs used were as follows: l-norepinephrine, dl propranolol hydrochloride, dl-pindolol, dl-5(3-tent-butylamino-2-hydroxy) propoxy-3,4 dihydrocarhostyril hydrochloride (OPC 1085, Otstika) (6) and dl-2,3-cis-1,2,3,4-tetrahydro

japanese journal of pharmacology/japanese journal of pharmacology

COMPARISON OF NEWLY SYNTHESIZED β-ADRENERGIC BLOCKERS, OPC 1085 AND SQ 11725, WITH PINDOLOL AND PROPRANOLOL IN THE BLOOD-PERFUSED CANINE SA NODE AND PAPILLARY MUSCLE PREPARATIONS