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From pharmacological, biochemical and histological evidence it has been suggested that catecholamines (CAs) may play an important role in the positive reinforcement of self stimulation (SS) (1-16). It is disputed, however, whether the rewarding effect of lateral hypothalamic stimulation depends on noradrenergic neurotransmission (7-13) or a dopa minergic one (14, 15) or both (16). On the other hand, the existence of epinephrine (Ep) neurons in the rat brain has recently been demonstrated using immunohistochemical methods (18). The effects of Ep on SS behavior, however, have not been examined. Hence in order to test which of these CAs are involved in the mediation of the lateral hypothalamic SS (LH-SS) behavior, the effects of CAs, injected into the lateral ventricle of the rat brain, on the behavior were examined in the present study. The effects of isoproterenol (Iso), a potent Q-adrenergic receptor agonist, were also investigated for the first time with regard to SS behavior. Male albino Wistar-Imamichi rats weighing 250-350 g were anesthetized with pen tobarbital sodium (50 mg/kg, i.p.). A bipolar electrode was stereotaxically implanted in or near the medial forebrain bundle (MFB) at the level of the posterior lateral hypothalamus. The electrode was made of a twisted pair of stainless steel wires insulated except for the tips, one of which was cut 0.3 mm shorter than the other. The electrode was connected to pins of a miniature socket which was then fixed to the skull with dental cement. Training of rats was started one week after the surgery in a Skinner box which was placed in a large wooden box equipped with a half mirror for observation. Each ]ever press delivered a 200 msec train of 0.5 msec rectangular pulses at 100 Hz through an adjustable constant current source devised by our group. A swivel, made also in our laboratory, prevented cable twisting. The rate of lever presses was recorded on a cumulative pen recorder (Ralph Gerbrands Co.) through a digital counter. The rat was trained for more than 20 min every day until a constant rate of lever presses was obtained. When drugs were injected, current intensity was decreased by steps of 10 microamperes so that rats might respond moderately enough to be facilitated by drugs. Drugs were injected into the lateral ventricle (1.0 mm posterior to bregma, 1.4 mm

Changes in the Self-Stimulation Behavior By Intraventricular Injection of Epinephrine, Norepinephrine , Isoproterenol And Dopamine