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Adenosine 3’, 5’-monophosphate (cyclic AMP) has been established as an intracellular mediator of the action of a number of amines and polypeptide hormones (1) and may well play an important role in the function of the central nervous system (2, 3). Although it has been shown that morphine induces alterations in the function of the endocrine system (4) and the metabolism of biogenic amines in the brain (5), little information is available concerning morphine induced changes in the metabolism of cyclic AMP in the brain.

EFFECT OF MORPHINE ADMINISTRATION ON ADENYL CYCLASE AND 3', 5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE ACTIVITIES IN THE BRAIN