English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

The electrophysiological and antiarrhythmic effects of LB-46 on the membrane potentials of Purkinje fibers and ventricular muscle fibers of the dog were studied by means of the microelectrode technique in comparison with those of propranolol. The effects of LB-46 on the membrane potential of Purkinje fibers consisted of a reduction in amplitude of the action potential due to a diminution or loss of overshoot and unchanged resting potential, an acceleration of repolarization, a prolongation of latency, and a decrease in mean rate of rise. Nearly the same electrophysiological effects were produced by propranolol at a lower concentration. LB-46, as well as propranolol, prevented the isoproterenol-induced arrhythmia by blocking the increase in diastolic depolarization. The antiarrhythmic action of LB-46 may be due considerably to direct action on the cardiac cell membrane and partly to a beta-receptor blockade. It is very probable that LB-46 is more specific in beta-receptor blocking and little weaker in antiarrhythmic activity than propranolol.

ELECTROPHYSIOLOGICAL AND ANTIARRHYTHMIC EFFECTS OF 4- (2-HYDROXY-3-ISOPROPYLAMINOPROPDXY) -INDOLE (LB-46) ON THE CANINE CARDIAC CELLS