English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

It is well known that the positive inotropic action of cardiac glycosides occurs in heart muscle cell, while in skeletal muscle cell such action does not appear (1-4). Such discrepant phenomenon would be, of course, related to a general problem on drug-receptor interaction and pharmacological receptor site. A series of experiments was done, therefore, on relationship between action of and intracellular concentration of cardiac glycosides in heart and skeletal muscle. Ventricle strip of heart and whole sartorius muscle of frog, Rana japonica, nd single fiber of leg muscle of shore crab, Chionoecetes opilio Fabricius, were used. Electrically stimulated heart strip (6/min) and sar torius muscle (1 /min) were soaked in frog Ringer's olution containing 'H-digitoxin or 'H-ouabain (concent ration: 1 x 10-6 g/ml) during upto 3 hours. In the case of single fiber of crab, crab saline (5) was used. The total radioactivity of these muscles was determined by the use of a liquid scintillation spectrometer (Nihon Musen) after complete dissolution with NCS Reagent (Nuclear Chicago) (6). Isometric twitch tension was

AVAILABILITY OF CARDIAC GLYCOSIDES FOR PHARMACOLOGICAL RECEPTOR-SITE OF MUSCLE CELLS AND POSITIVE INOTROPIC ACTION