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‰Á " ¡ —²ˆê Kato et al. (1-3) and Booth and Gillette (4) demonstrated that the sex difference in the activities of drug-metabolizing enzyme systems of rat liver microsomes is related to the anabolic action of male sex hormone. In fact, they demonstrated increases in the activities of drug-metabolizing enzymes of liver microsomes of castrated female rats by the treatment with synthetic hormones , such as 4 chlorteststerone and 19-norteststerone.

SEX DIFFERENCE IN THE ACTIVITIES OF MICROSOMAL DRUG-METABOLIZING ENZYME SYSTEMS IN RELATION TO DIETARY PROTEIN