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The depletion of catecholamine in the brain, heart, adrenal medulla and other sympathetically innervated tissues by acutely administered-reserpine has been demonstrated by Hillarp (1), Holzbauer and Vogt (2), Kroneberg and Schumann (3) and Mirkin (4). The depletion of the level of the amine in the adrenal medulla during insulin hypoglycemia in cat (5) and rat (6, 7), by administration of eserine in rat (8) and by repeated administration of acetylcholine in cat (9, 10) was already confirmed. Similar depletion of the amine in the adrenal medulla of eviscerated cat by stimulation of splanchnic nerve was shown by West (11) and Holland and Schumann (12). The loss of the amine from the adrenal medulla by a single dose of reserpine has been attributable mainly to stimulation in the central nervous system which was conducted to the organ by way of the splanchnic nerve ; because spinal section at T2 (13) or severance of splanchnic nerve (3) markedly diminished the effect in rat and cat. Vogt (14), Vogt and Holzbauer (2, 15) studied the effects of some drugs including central stimulants on the content of catecholamine in the hypothalamus, and in the innervated and denervated adrenal gland of cat and dog. Among the drugs tested, insulin, morphine and beta-tetrahydronaphthylamine proved to deplete effectively the amine in the hypothalamus and in the innervated adrenal gland. There was also an excellent correlation between the loss of hypothalamic amine and the stimulation of sympathetic center resulting in a loss of the amine in the innervated adrenal gland. In this laboratory Shimamoto and Torii (16) studied the effects of intravenous and intracarotid injections of reserpine on the hypothalamic pressor response and on behavior in rabbit. They obtained the evidence that though the intravenous injection of reserpine revealed a marked depression of the hypothalamic pressor response and a usual sedation, the intracarotid injection did not reveal any effect. In relation to their results, this series of experiments was attempted to study the effects of intravenous and intracarotid injections of reserpine on the content of catecholamine in the brain, heart and adrenal gland of rabbits.

EFFECTS OF INTRAVENOUS AND INTRACAROTID ADMINISTRATION OF RESERPINE ON CATECHOLAMINE CONTENTS OF THE BRAIN, HEART AND ADRENAL GLAND IN RABBIT