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This review describes: 1. Recent findings about the physiological and pharmacological actions of kyotorphin that was isolated from the brain. 2. Biosynthesis, distribution, release, uptake, enzymatic destruction of this peptide in the body. 3. L-Arginine was found to be a precursor of kyotorphin. 4. Clinical application of the precursor to the treatment of chronic pain.

Physiological and pharmacological actions of a neuroactive dipeptide, kyotorphin, and its precursor, L-arginine, and clinical application.