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Effects of 3,4-diaminopyridine (DAP), which decreases the membrane K conductance, on the contractions of guinea-pig tracheal smooth muscle induced by histamine and prostaglandin D2 (PGD2) were investigated. Pretreatments with 5 X 10(-4) and 10(-3) M DAP increased the excitability of histamine-induced contraction. The increment of the excitability by DAP was not suppressed by tetrodotoxin (TTX), but by nifedipine (Nif). Pretreatment with 10(-3) M DAP did not affect the contraction induced by PGD2. The results suggest that DAP increases the excitability of histamine-induced contraction by activating the voltage-dependent Ca channels and that PGD2 contracts tracheal smooth muscle through a mechanism different from that of histamine.

Effects of 3,4-diaminopyridine on the contractions of guinea-pig tracheal smooth muscle induced by histamine and prostaglandin D2.