English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

The cause of sex differences in the pressor response to l-adrenaline in adult rats (Tomori, 1986) was further examined using normal and castrated adult rats. Blood pressure was determined by the tail-cuff method. A prolonged elevation of blood pressure in male rats shown after an injection of l-adrenaline (50 micrograms/kg, s.c.) was almost completely suppressed by phentolamine (50 micrograms/kg, s.c.), and the slight l-adrenaline-induced increase in blood pressure in female rats was reversed to a decrease by phentolamine. Pretreatment with propranolol (200 micrograms/kg, s.c.) enhanced the pressor action of l-adrenaline in males and enhanced it to a greater extent in females. Castration resulted in a significant decrease in basal pressure in males and no change in females. Pressor responses to l-adrenaline in castrated male and female rats showed a minor alteration. In clonidine (20 micrograms/kg, s.c.)-treated normal rats, l-adrenaline induced an increase in blood pressure in males, but caused a decrease in females. In clonidine-treated castrated male rats, however, l-adrenaline administration induced a decrease in blood pressure. l-Adrenaline injection to yohimbine (1 mg/kg, s.c.)-treated rats induced a prolonged elevation of blood pressure in males and a transient elevation in females as shown in rats treated with l-adrenaline alone. In yohimbine-treated castrated rats, a decrease in the blood pressure was observed in males and a slight increase was observed in females after l-adrenaline administration. The present results suggest that the central pressor regulatory system is involved in the sex difference in pressor response to exogenous l-adrenaline and that androgens play a role to somehow maintain a higher pressor responsiveness to l-adrenaline in male rats.

Sexual dimorphism in the pressor response to l-adrenaline in rats.