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Accumulating evidence shows astrocytic contribution to brain function and diseases, however, the function of astrocytes remains to be uncovered. Dynamic changes in the intracellular Ca 2+ level in astrocytes are one of the outstanding indexes of ongoing astrocytic activity. Therefore, we tried to uncover astrocytic function using approaches combined with Ca 2+ imaging. We showed that astrocytes promote neuronal growth and survival after injury via Ca 2+ -dependent regulation of a cell adhesion protein, N-cadherin. Furthermore, we developed a method for the monitoring of astrocytic Ca 2+ signals in living mouse brain, and found a previously unidentified pattern of spontaneous Ca 2+ signals, which are preferably displayed in astrocytic fine processes. These findings and methods are promising to provide further information of astrocytic function, which can contribute to development of pharmacology.

Analysis of astrocytic function using Ca<sup>2+</sup> imaging