English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

This article describes current information concerning analyses of contraction and relaxation associated with electrical stimulation of efferent nerves in isolated mammalian sphincter muscles. Contractile responses of sphincters are mediated by alpha 1-adrenoceptors and muscarinic receptors stimulated by transmitters from adrenergic and cholinergic nerves, respectively, whereas those of the bladder body are almost exclusively mediated by transmitters from parasympathetic nerves. Relaxant responses to nerve stimulation are ascribed mainly to mechanisms that are sensitive and resistant to nitric oxide (NO) synthase inhibitors. Neurogenic calcitonin gene-related peptide and beta-adrenoceptor activation by neurogenic norepinephrine may also be involved in some mammals. Stimulus frequency is an important determinant to distinguish NO synthase-sensitive and -resistant components; responses at low frequencies are abolished by the enzyme inhibitors, whereas those at high frequencies are inhibited only partially. High and low frequency stimulation increases the cyclic GMP content in muscles, suggesting the involvement of neurogenic NO, although relaxation at high frequencies is only partially due to such a mechanism. From pharmacological studies so far analyzed, including ours performed with porcine urinary tract sphincters, it is concluded that NO synthase resistant-relaxation is not mediated by peptides nor compounds that open K+ channels in muscle cell membrane and stimulate beta-adrenoceptors. Contribution of NO and non-NO relaxing factor (s) in relaxant responses varies with animal species. Identification of this factor, determination of intracellular signaling processes and interaction with the NO/cyclic GMP system may give us a clue in developing new therapeutics to treat dysfunctions of the lower urinary tract sphincters.

Regulation by autonomic nerves of bladder neck sphincter function-mainly on inhibitory NANC nerves-