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The inhibitory effect of ethanol absorption by zinc cysteine (Cys-Zn) and zinc acetylcysteine (ACys-Zn) were studied in mice. This mice orally received Cys-Zn, ACys-Zn, Cys or Zn acetate, and after 1 hr, 14C-ethanol was given orally or intraperitoneally (i.p.). At various times, blood was drawn from the tail vein and 14C-radioactivities determined. Cys-Zn and ACys-Zn inhibited the appearance of 14C-radioactivities in blood following oral 14C-ethanol loading, but Cys and Zn acetate caused no changes as compared to the control. Cys-Zn pretreatment did not induce any change in the blood 14C-radioactivity when ethanol was given i.p. The levels of 14C-radioactivity and zinc in the gastrointestinal tract after oral administration (adm) of Cys-Zn and 14C-ethanol were significantly higher than those of the control for 7 hr. At 72 hr after adm, the urinary and fectal excretions of 14C-radioactivity were low when Cys-Zn was given at the dose of 5.0% or 0.5%. The excretion of 14C-radioactivity through expiration in both cys-Zn and control mice was about 28% of the dose at 5 hr after adm. Distributions of 14C-radioactivities in other organs of Cys-Zn treated mice were lower then those of the control. In the vitro study, Cys-Zn stimulated the metabolism of ethanol to acetaldehyde and acetic acid in the 9,000 g supernatant of the small intestine. The results suggest that zinc complex shows a long-term adhesive and permeable action on the gastrointestinal tract in mice, and this inhibited ethanol absorption.

The inhibitory effect and the mechanism of ethanol absorption by zinc complex in mouse gastrointestinal tract.