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eellulose, The btnding of palmitate to this protein was saturable end the molecular wetght determined hy SDS-PACE was IS,500. BindinB aetivity fDr AA was greater in young SHR (Sweeks)(cortex 6,]4 ±O.71 ± , medulla 8.23+O.43t nmo17mg pTotetn. mean+SD, n=6) than in age-matched Wistar-Kyoto rats (WKY)(2.09+O.35, 1.96+O.25). However in old SHR (40 weeks), FABP actlvity was reduced (1.51+ O.20. 1.61+O.29) and similar to that in agematehed WKY (1.46+O.27, 1.54+O.16). AA amount tn total hemogenate phepholipids determined by gas chromatography was hl$o grenter in young SHR (14,3+O,5tt, 27,3+9.4" pg/mg protein) than in age-matched WKY (9.7+O,5. 2,9+O.2). In old SHR, AA amount was reduced {10.1+O.S, 10.6+1.1"kth) and similaT to that in age-matched WE(Y (10.1+e.1, 4.1 +O.2). In conclusion, fatty acid metaboltsm in kidney may be regulated by FABP, whose increased activity for AA in yeung SHR, accompanied wtth a rise in AA amount, may be related to the development of hypertension through increased PGs synthesis in the kidney. (ikp

-92-RAT KIDNEY FATTY ACID BINDING PROTEIN : INCREASED BINDING ACTIVITY IN SPONTANEOUSLY HYPERTENSIVE RATS