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The electrophysiological effects of nicardipine-HCl, a new calcium antagonist and potent vasodilator, were studied in the isolated sinoatrial (SA) and atrio-ventricular (AV) nodes of the rabbit in an oxygenated Tyrode solution at 35 degrees C using an intracellular microelectrode technique. Nicardipine-HCl decreased the spontaneous rate of the SA node and prolonged sinus recovery time, dose-dependently. The effective refractory period (ERP) and functional refractory period (FRP) of the AV node and AV conduction time (A-H interval) were also prolonged by nicardipine-HCl in a dose-dependent manner. In conclusion, nicardipine-HCl has electrophysiological effects on the SA and the AV node similar to those of other calcium antagonists in the excised and superfused rabbit heart.

Electrophysiological effects of nicardipine hydrochloride on the isolated sinoatrial and atrioventricular nodes of the rabbit.