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In a total of 6 patients with rheumatic fever, antistreptolysin O (ASO), antistreptodeoxyribonuclease-B (ADNase-B) and antistreptokinase (ASK) titer was followed up for 3 months to 6 years. The mean periods of time of normalization of these serological tests were 4 months in ASO, 35 months in ADNase-B. In ASK, the period varied vastly in the range from 5 weeks to 4 years 1 month. Clinically it is not so easy to differentiate rheumatic heart disease from mitral valve disease of unknown etiology. In the case of high ADNase-B level, the patients my be considered to have been attacked by rheumatic fever sometime during a preceding period of as long as about 35 months.

Follow-up study of ASO, ADN-B and ASK levels in children with rheumatic fever.