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Prompt and potent antiplatelet effects are important aspects of management of ST-elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PPCI). We evaluated the association between platelet-derived thrombogenicity during PPCI and enzymatic infarct size in STEMI patients.Methods and Results:Platelet-derived thrombogenicity was assessed in 127 STEMI patients undergoing PPCI by: (1) the area under the flow-pressure curve for the PL-chip (PL 18 -AUC 10 ) using the total thrombus-formation analysis system (T-TAS); and (2) P2Y 12 reaction units (PRU) using the VerifyNow system. Patients were divided into 2 groups (High and Low) based on median PL 18 -AUC 10 during PPCI. PRU levels during PPCI were suboptimal in both the High and Low PL 18 -AUC 10 groups (median [interquartile range] 266 [231-311] vs. 272 [217-317], respectively; P=0.95). The percentage of final Thrombolysis in Myocardial Infarction (TIMI) 3 flow was lower in the High PL 18 -AUC 10 group (75% vs. 90%; P=0.021), whereas corrected TIMI frame count (31.3±2.5 vs. 21.0±2.6; P=0.005) and the incidence of slow-flow/no-reflow phenomenon (31% vs. 11%, P=0.0055) were higher. The area under the curve for creatine kinase (AUC CK ) was greater in the High PL 18 -AUC 10 group (95,231±7,275 IU/L h vs. 62,239±7,333 IU/L h; P=0.0018). Multivariate regression analysis identified high PL 18 -AUC 10 during PPCI (β=0.29, P=0.0006) and poor initial TIMI flow (β=0.37, P&lt;0.0001) as independent determinants of AUC CK .

circulation journal

Platelet-Derived Thrombogenicity Measured by Total Thrombus-Formation Analysis System in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention