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after the treatment. The 15-min treatment of the autopericardium makes it too hard for this purpose. We know that most congenital cardiac surgeons in Japan use the 1–2-min preserved autopericardium as a patch to repair ventricular septal defects or other congenital cases; their results have been good and established the position of routine maneuver. We do not have enough scientific data on the sufficiency of cross-linking in the mitral tissue and autopericardium, but we hope that our experience will consolidate the data in the future. Thank you very much for your letter.

A Concern About 2-Minute Glutaraldehyde-Treated Autologous Pericardium for Mitral Valve Repair ― Reply ―